European Journal of Integrative Medicine
Volume 1, Issue 3 , Pages 131-137 , October 2009

Pharmacological evaluation of anticonvulsant activity of root extract of Saussurea lappa in mice

Received 1 July 2009 ,Revised 11 August 2009 ,Accepted 27 August 2009.

References 

  1. Reddy DS. Pharmacotherpy of catamenial epilepsy. Indian J Pharmacol. 2005;37:288–293
  2. Mattson RH. Efficacy and adverse effects of established and new antiepileptic drugs. Epilepsia. 1995;36:S13–S16
  3. Phillipson JD. 50 years of medicinal plant research-every progress in methodology is a progress in science. Planta Med. 2003;69:491–495
  4. Kirtikar KR,Basu BD. 2nd ed Indian medicinal plants, vol. 2. Deharadun, India: International Book Distributors; 1987 (p. 1326–8)
  5. Gupta NNS. The ayurvedic system of medicine. vol. 2. New Delhi: Logas Press; 1984;(p. 411–6)
  6. Sastri BN, editor. The wealth of India (A dictionary of Indian raw materials and industrial products): raw materials, vol. 2. New Delhi: Council of Scientific and Industrial Research; 1989 (p. 173).
  7. In:  Nadkarni KM editors. Indian materia medica. vol. 1:Mumbai: Bombay Popular Prakashan; 1993;(p. 185–6)
  8. Paul A, Bawdekar AS, Joshi RS, Kulkarni GH, Rao AS, Kelkar GR, et al. Terpenoids XX: examination of costus root oil. Perf Essent Oil Rec. 1960;115–120
  9. Govindan SV, Bhattacharyya SC. Alantolides and cyclocostunolides from Saussurea lappa Clarke (Costus root). Ind J Chem. 1977;15B:956–957
  10. Kulkarni GH, Bawdekar AS, Rao AS, Kelkar GR, Bhattacharyya SC, Terpenoids XLIV. Examination of Costus root oil. Part IV. Perf Essent Oil Rec. 1963;303–311
  11. Jain TC, Banks CM. 22-Dihydrostigmosterol from Saussurea lappa Clarke. Can J Chem. 1968;46:2325–2327
  12. Bawdekar AS, Kelkar GR. Terpenoids – LXVIII: structural and absolute configuration of costic acid – a new sesquiterpenic acid from costus root oil. Tetrahedron. 1965;21:1521–1528
  13. Kalsi PS, Sharma S, Kaur G. Isodehydrocostus lactone and isozaluzanin C, two guainolides from Saussurea lappa. Phytochemistry. 1983;22:1993–1995
  14. Yoshikawa M, Hatakeyama S, Inoue Y, Yamahara J, Saussureamines A. B, C, D & E, new artiulcer principles from Chinese Saussureae Radix. Chem Pharm Bull. 1993;41:214–216
  15. Dwivedi S, Somasi PN, Chansouria JPN, Vdupa KN. Cardioprotective effects of certain indigenous drugs in myocardial ischaemia in rabbits. Ind J Exp Biol. 1988;26:969–997
  16. Bose BC, Saifi AQ, Vijayvargiya R, Sharma SK. Some aspect of phytochemical and pharmacological study of Saussurea lappa Clarke. J Pharm Sci. 1961;51:679–681
  17. Yamahara J, Kobayashi M, Mlki K, Koruta M, Sawada T, Fujimula H. Cholagogic and antiulcer effect of Saussurea radix and its active components. Chem Pharm Bull. 1985;33:1285–1288
  18. Lee MG, Lee KT, Chi SG, Park JH. Costunoilde induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. Bio Pharm Bull. 2001;24:303–306
  19. Cho JY, Baik KU, Jung JH, Park MH. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol. 2000;398:399–407
  20. Chen HC, Chou CK, Lee SD, Wang J, Yeh SF. Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. Antiviral Res. 1995;27:99–109
  21. Matsuda H, Toguchida I, Ninomiya K, Kageura T, Morikawa J, Yoshikawa M. Effects of sesquiterpenes and amino acid sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide activated macrophages. Bioorg Med Chem. 2003;11:709–715
  22. Jeong SJ, Itokawa T, Shibuya M, Kuwano M, Ono M, Higuchi R, et al. Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the KDR/Flk-1 signaling pathway. Cancer Lett. 2002;187:129–133
  23. Trease EG, Evans WC. Textbook of pharmacognosy. 12th ed. Singapore: Alden Press; 1983;(p. 539–41)
  24. Swinyard EA, Brown WC, Goodman LS. Comparative assays of antiepileptic drugs in mice and rats. J Pharmacol Exp Ther. 1952;106:319–330
  25. In:  Vogel HG,  Vogel WH editor. Drug discovery and evaluation: pharmacological assays. 2nd ed. New York: Springer; 2002;p. 421–424
  26. Olsen RW, Avoli M. GABA and epileptogenesis. Epilepsia. 1997;38:399–407
  27. McNamara JO. Drugs effective in therapy of the epilepsies. In:  Hardman JG,  Limbard LE editor. Goodman and Gilman's the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill, Health Professional Division; 1996;(p. 461–86)
  28. Insel TR, Ninan PT, Aloi J, Jimerson DC, Skolnick P, Paul SM. A benzodiazepam receptor-mediated model of anxiety studies in nonhuman primate and clinical implications. Arch Gen Psychiatry. 1984;41:741–750
  29. Weiss JM, Goodman PA, Losito BG, Corrigan S, Charry JM, Biley WH. Behavioural depression produced by uncontrollable stressor: relationship to norepinephrin, dopamine and serotonin level in various region of rat brain. Brain Res Rev. 1981;3:167–205
  30. Calabrese EJ. U-shaped dose response in behavioral pharmacology: historical foundations. Crit Rev Toxicol. 2008;38:591–598
  31. Walsh LA, Li M, Zhao T, Chiu T, Rosenberg HC. Acute pentylenetetrazole injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J Pharmacol Exp Ther. 1999;289:1626–1633
  32. Macdonald RL, Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia. 1995;36:S2–S12
  33. Coulter DA, Hugenard JR, Prince DA. Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol. 1989;25:582–593
  34. Loscher W, Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 1988;2:145–181
  35. Ha JH, Lee DU, Lee JT, Kim JS, Yong CS, Kim JA, et al. 4-hydroxybenzaldehyde from Gastrodia elata B1 is active in the antioxidation and GABAergic neuromodulation of the rat brain. J Ethnopharmacol. 2000;73:329–333
  36. Silva B, Elisabetsky E, Souza D. Effects of linalool. Phytotherapy Res. 2001;15:422–425
  37. Taesotikul T, Panthong A, Kanjanapothi D, Verpoorte R, Scheffer JC. Neuropharmacological activites of the crude alkaloidal fraction from stems of Tabernaemontana pandacaqui poir. J Ethnopharmacol. 1998;62:229–234
  38. Dallmeier K, Carlini EA. Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogue. Pharmacology. 1981;22:113–127
  39. Dhawan K, Kumar S, Sharma A. Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. J Ethnopharmacol. 2001;78:165–170
  40. Rabbani M, Sajjadi SE, Zarei HR. Anxiolytic effects of Stachys lavandulifolia Vahl on the elevated plus-maze model of anxiety in mice. J Ethnopharmacol. 2003;89:271–276
  41. Vale TG, Motos FJA, De Lima TCM, Viana GSB. Behavioral effects of essential oils from Lippa alba (Mill) N.E. Broen Chemotypes. J Ethnopharmacol. 1999;167:127–133
  42. Yuan CS, Attele AS, Wu JA, Liu D. Modulation of American genseng on brainstem GABAergic effects in rats. J Ethnopharmacol. 1998;62:215–222
  43. Nougueira E, Rosa GJM, Haraguchi M, Vassilieff VS. Anxiolytic effect of Rubus brasilensis in rats and mice. J Ethnopharmacol. 1998;61:111–117

PII: S1876-3820(09)00199-1

doi: 10.1016/j.eujim.2009.08.159

European Journal of Integrative Medicine
Volume 1, Issue 3 , Pages 131-137 , October 2009

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