European Journal of Integrative Medicine
Volume 2, Issue 2 , Pages 71-77, June 2010

Immune messengers in Neuralgia Inducing Cavitational Osteonecrosis (NICO) in jaw bone and systemic interference

  • J. Lechner

      Affiliations

    • Grünwalder Str. 10A, D-81547 München, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 89 697 00 55; fax: +49 89 692 58 30.
    web address
    • ,
  • W. Mayer

      Affiliations

    • Immumed – Gesellschaft für angewandte Immunologie, Goethestraße 10, D-80336 München, Germany
    • Tel.: +49 89 543 21 77 89; fax: +49 89 543 21 77 82.

Received 7 January 2010; received in revised form 24 March 2010; accepted 31 March 2010. published online 08 August 2011.

Abstract 

Aim of the study

In the practice of the author astounding improvements of systemic complaints which accompanied apparently rheumatic, neuralgic and other chronically inflammatory systemic diseases are consistently observed after cleaning pain free, radiographically normal edentulous areas of the jaw. These are marked by fatty-degenerative osteonecrosis of the cancellous bone. Thus far, in dental research there are only few scientifically proven explanations concerning such systemic therapeutic successes.

Methods

In order to clarify systemic interrelations, samples of cancellous bone have been extracted from six subjects. The specimens were then analyzed by bead-based multiplex technology and tested for 27 immune messengers.

Results

All six specimens concordantly showed highest concentration for IL1-ra (interleukin-1-receptor antagonist) and RANTES. In addition, in all samples FGFbasic and PDGF-bb have been distinctly evidenced. A statistically high concentration on IL1-RA and RANTES is noticeable here. The samples’ small distribution and specific concentration on IL1-ra and RANTES, despite the high number of 27 tested mediators, is a striking figure.

Keywords: NICO, Immune messenger, RANTES, Proinflammatory cytokines, Osteonecrosis, Systemic interference

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PII: S1876-3820(10)00026-0

doi:10.1016/j.eujim.2010.03.004

European Journal of Integrative Medicine
Volume 2, Issue 2 , Pages 71-77, June 2010

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